Q. what is the definition of substance abuse dependence misuse
I did a bit of searching for that phrase, and so far have only found that particular combination of words in one place. It shows up on page 353 of Handbook of Consultation-Liaison Psychiatry by Hoyle Leigh, Jon Streltzer (first edition 2007).
You should be able to take a peek at the page by going to this web address: http://books.google.com/books?isbn=0387692533 and searching within the book for "substance abuse dependence misuse".
The phrase is used in the book as a kind of heading, and from the context of what that section of the book talks about, it seems to be being used as a combination term to include "substance abuse" plus "substance dependence" plus "substance misuse."